Yes, my (awesome) Chicony natural keyboard (with ps/2 cable) does work with my Mac Mini.
The trick when first plugging in the keyboard with the ps/2 to USB adapter: when OS.x asks
"what key is immediately to the right of the left shift key"?
the answer is to lie and say it is the Cmd (Windows) key.
In reality the Z key is to the right of the shift key, but that answer will result in the keyboard not being recognized. Pretend it is the Cmd key.
Also, when the shit hits the fan (such as the mouse and/or keyboard start acting wacky) unplug the keyboard and plug it in again.
